Li (Alex) Zuo, PhD,

Dr. Zuo is a Fellow of the American College of Sports Medicine. He has OSU-P status with the Graduate School and is advising MS or PhD students at The Ohio State University. Zuo is also a faculty member of OSU Biophysics Graduate Program. Zuo’s research objective is to study the biological function of respiratory muscle using noninvasive methodology and preconditioning therapies. Zuo’s group is developing the stem cell treatments for respiratory muscle dysfunction in chronic obstructive pulmonary disease (COPD).

Dr. Zuo is a Fellow of the American College of Sports Medicine. He has OSU-P status with the Graduate School and is advising MS or PhD students at The Ohio State University. Zuo is also a faculty member of OSU Biophysics Graduate Program. Zuo’s research objective is to study the biological function of respiratory muscle using noninvasive methodology and preconditioning therapies. Zuo’s group is developing the stem cell treatments for respiratory muscle dysfunction in chronic obstructive pulmonary disease (COPD). Zuo’s research emphasizes on the molecular and cellular mechanism of stress-induced free radicals formation in skeletal and cardiac muscle. Particularly his team aims at identifying new roles of free radicals on diverse disease models such as cardiovascular ischemia/reperfusion injuries, skeletal muscle dysfunction in hypoxia, and COPD induced damage on respiratory muscle. Currently, Dr. Zuo serves as the Academic Editor for PeerJ and Associate Editor for Frontiers in Striated Muscle Physiologyand Frontiers in Physiology.

EDUCATION

Ph.D. in Biophysics and Physiology, Ohio State University 

TEACHING

Human Physiology; Pathophysiology; Physiology Laboratory

Current Courses of Instruction

RST 4615 Clinical Correlations 

SELECTED PUBLICATIONS 

Rong Y, Evans J, Xu-Welliver M, Pickett C, Jia G, Chen Q*, Zuo L*. Dosimetric evaluation of intensity-modulated radiotherapy, volumetric modulated arc therapy, and helical tomotherapy for hippocampal-avoidance whole brain radiotherapy. PLoS One 10:e0126222; 1-12, 2015 (*Corresponding author).

Zuo L*, Best TM, Roberts WJ, Wagner PD. Characterization of reactive oxygen species in diaphragm. Acta Physiol 213: 700-10, 2015 (*Corresponding author).

Zuo L, Hemmelgarn BT, Jouett NP, Smith ML, Eugenín J, Beltrán-Castillo S, von Bernhardi R, de Figueiredo Müller-Ribeiro FC, Ribeiro-Marins F, Fontes MA, Cysique LA, Gandevia SC, Tellez HF, Mekjavic IB, Perlitz V, Kerkhof PL, de Munck J, Moret-Bonillo V, Nieman G, Gatto LA. Commentaries on Viewpoint: The ongoing need for good physiological investigation: Obstructive sleep apnea in HIV patients as a paradigm. J Appl Physiol 118: 247-50, 2015.

Zuo L*, Diaz PT, Chien MT, Roberts WJ, Kishek J, Best, TM, Wagner, PD. PO2 cycling reduces diaphragm fatigue by attenuating ROS formation. PLoS ONE 9:e109884;1-9, 2014 (*Corresponding author).

Cheng H, Wang L, Mollica M, Re AT, Wu S*, Zuo L*. Nitric oxide in cancer metastasis. Cancer Lett 353: 1-7, 2014 (*Corresponding author). 

Zuo L*, He F, Sergakis GG, Koozehchian MS, Stimpfl JN, Rong Y, Diaz PT, Best TM. The interrelated role of cigarette-smoking, oxidative stress and immune response in COPD and corresponding treatments. Am J Physiol Lung Cell Mol Physiol 307: L205-L218, 2014 (*Corresponding author).

Jiang L, Diaz PT, Best TM, Stimpfl JN, He F, Zuo L*.  Molecular characterization of redox mechanisms in allergic asthma. Ann Allergy Asthma Immunol 113:137-142, 2014 (doi: 10.1016/j.anai.2014.05.030; *Corresponding author).

Rong Y, Chen Y, Shang L, Zuo L, Lu W, Chen Q. Helical tomotherapy with dynamic running-start-stop delivery compared to conventional tomotherapy delivery. Med Phys 41: 051709, 2014.

Zuo L*, Rose BA, Roberts WJ, He F, Banes-Berceli AK. Molecular characterization of reactive oxygen species in systemic and pulmonary hypertension. Am J Hypertens 27: 643-50, 2014 (*Corresponding author).

Zuo L*, Hallman AH, Roberts WJ, Wagner PD, Hogan MC. Superoxide release from contracting skeletal muscle in pulmonary TNF-α overexpression mice. Am J Physiol Regul Integr Comp Physiol 306: R75-R81, 2014, 2013; *Corresponding author).

Zuo L*, Koozechian MS, Chen LL. Characterization of reactive nitrogen species in allergic asthma. Ann Allergy Asthma Immunol, 112: 18-22, 2014 (*Corresponding author).

Chang Q, Zuo L*. The biophysical model for accuracy of cellular sensing spatial gradients of multiple chemoattractants. Phys Biol 10 (056014), 1-8, 2013 (*Corresponding author).

Zuo L, Shiah A, Roberts WJ, Chien MT, Wagner PD, Hogan MC. Low PO2 Conditions Induce reactive oxygen species formation during contractions in single skeletal muscle fibers. Am J Physiol Regul Integr Comp Physiol 11: R1009-16, 2013 (Corresponding Author).

Zuo L, Otenbaker, NP, Rose BA, Salisbury, KS. Molecular mechanisms of reactive oxygen species-related pulmonary inflammation and asthma. Mol Immunol 56, 57-63, 2013 (Corresponding Author).

Zuo L, Nogueira L, Hogan MC. Effect of pulmonary TNF-α overexpression on mouse isolated skeletal muscle function. Am J Physiol Regul Integr Comp Physiol 301: R1025–R1031, 2011 (Corresponding Author). 

Zuo L, Nogueira L, Hogan MC. Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers. J Apply Physiol 111: 898-904, 2011 (Corresponding Author).

Zuo L, Youtz DJ, Wold LE. Particulate matter exposure exacerbates high glucose-induced cardiomyocyte dysfunction through ROS generation. PLoS ONE 6: e23116, 1-7, 2011.

Zuo L, Chen YR, Reyes LA, Lee HL, et al. The   Radical Trap 5,5-Dimethyl-1-pyrroline N-oxide Exerts Dose-Dependent Protection Against Myocardial Ischemia-Reperfusion Injury Through Preservation of Mitochondrial Electron Transport.  J Pharmacol Exp Ther. 329:515-523, 2009

Zhu X, Zuo L, Cardounel AJ, et al. Characterization of in vivo tissue redox status, oxygenation, and formation of reactive oxygen species in postischemic myocardium. Antioxid Redox Signal. 9: 447-55, 2007. 

Zuo L, Clanton TL, Reactive oxygen formation in the transition to hypoxia in skeletal muscle. Am J Physiol Cell, 289: C207-C216, 2005.

Zuo L, Christofi FL, Wright VP, Bao S, Clanton TL. Lipoxygenase-dependent superoxide release in skeletal muscle.  J Appl Physiol 97:661-668, 2004.

Zuo L, Pasniciuc S, Wright VP, Merola AJ, Clanton TL. Sources of superoxide release: Lessons from blockade of electron transport, NADPH oxidase and anion channels in diaphragm. Antioxid Redox Signal 5: 667-675, 2003

Zuo L, Christofi FL, Wright VP, Liu CY, Merola AJ, Berliner LJ, Clanton TL. Intra- and extracellular measurement of reactive oxygen species produced during heat stress in diaphragm muscle. Am J Physiol Cell 279: C1058-C1066, 2000.